Quick Answer: How Long Does Chloroquine Stay In The Body?

What is the half life of chloroquine?

45 to 55 daysThe estimated terminal elimination half-life is 45 to 55 days for chloroquine and 59 to 67 days for its active metabolite desethylchloroquine.

Chloroquine is detectable in the urine for up to a year after drug administration..

Can you overdose on chloroquine?

An overdose of chloroquine can be fatal, and must be treated quickly. Overdose symptoms may include drowsiness, vision changes, seizure, slow heart rate, weak pulse, pounding heartbeats, sudden dizziness, fainting, shortness of breath, or slow breathing (breathing may stop).

Can chloroquine cause blindness?

Blindness from Chloroquine is irreversible and unfortunately visual loss will progress despite cessation of therapy. Three patients with retinopathy are told to stop using chloroquine and use alternative antimalarials. Most of these patients with low vision will benefit from low vision aids.

What is the generic name of chloroquine?

Chloroquine, brand name Aralen, is an anti-malarial drug. It is similar to hydroxychloroquine (Plaquenil), and is useful in treating several forms of malaria as well as amebiasis that has spread outside of the intestines.

Is chloroquine available over the counter?

Chloroquine and proguanil is available as an over the counter medicine from your pharmacy, so you don’t need to see a doctor for a prescription in order to be able to buy it. However, it is important that you make sure that it will protect you from the malaria parasites endemic to the region you are travelling to.

How long does chloroquine stay in the system?

Both chloroquine and desethyl chloroquine concentrations decline slowly, with elimination half lives of 20-60 days. Both parent drug and metabolite can be detected in urine months after a single dose[26].

What are the negative effects of chloroquine?

Nausea, vomiting, abdominal cramps, headache, and diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

What happens when you take chloroquine?

Taking chloroquine long-term or at high doses may cause irreversible damage to the retina of your eye that could progress to permanent vision problems. You may not be able to use chloroquine if you have a history of vision changes or damage to your retina.

Is chloroquine hard on kidneys?

It is concluded that chloroquine administration impairs kidney function, resulting in inappropriate Na + and Cl− retention. This effect is likely to be mediated via chloroquine-induced increases in plasma aldoster-one concentration and lowering of GFR.

Is chloroquine a steroid?

Steroid-sparing treatments have been sought and one of these is chloroquine. Chloroquine is an anti-inflammatory agent, also used in the treatment of malarial infection and as a second-line therapy in the treatment of rheumatoid arthritis, sarcoidosis and systemic lupus erythematosus.

What does quinine do to the body?

Among the most serious potential side effects associated with quinine are: bleeding problems. kidney damage. abnormal heartbeat.

Can you drink alcohol with chloroquine?

The consumption of alcoholic beverages both simultaneously or following the oral administration of CQ does not reduce the amount of CQ absorbed and hence may not be the cause of drug failure. Keywords: Absorption, Alcohol, Chloroquine, intestine, stomach.

Can chloroquine cause psychosis?

Although neuropsychiatric adverse effects of chloroquine use have been reported, they are rare, and the risk ratio has been estimated to be 1:13,600. Psychosis in both adults3-5 and children6-8 due to chloroquine use has been widely described in case reports.